{"type":"standard","title":"Gabriela Leite","displaytitle":"Gabriela Leite","namespace":{"id":0,"text":""},"wikibase_item":"Q10287931","titles":{"canonical":"Gabriela_Leite","normalized":"Gabriela Leite","display":"Gabriela Leite"},"pageid":19019043,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Gabriela_leite_daspu.jpg/330px-Gabriela_leite_daspu.jpg","width":320,"height":480},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/d/d1/Gabriela_leite_daspu.jpg","width":1066,"height":1599},"lang":"en","dir":"ltr","revision":"1273128907","tid":"cb8676a5-e01e-11ef-a07f-3c1fcd7fa678","timestamp":"2025-01-31T22:00:34Z","description":"Brazilian prostitute and sex workers' rights campaigner (1951-2013)","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Gabriela_Leite","revisions":"https://en.wikipedia.org/wiki/Gabriela_Leite?action=history","edit":"https://en.wikipedia.org/wiki/Gabriela_Leite?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Gabriela_Leite"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Gabriela_Leite","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Gabriela_Leite","edit":"https://en.m.wikipedia.org/wiki/Gabriela_Leite?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Gabriela_Leite"}},"extract":"Gabriela Silva Leite was a Brazilian prostitute and activist in support of the rights of sex workers. She was the founder of the NGO, Davida, which derives its name from \"Mulheres da Vida\", a term commonly used for prostitutes in Brazil, and of Daspu, a fashion brand for prostitutes.","extract_html":"
Gabriela Silva Leite was a Brazilian prostitute and activist in support of the rights of sex workers. She was the founder of the NGO, Davida, which derives its name from \"Mulheres da Vida\", a term commonly used for prostitutes in Brazil, and of Daspu, a fashion brand for prostitutes.
"}{"slip": { "id": 195, "advice": "Exercise in the rain can really make you feel alive."}}
{"type":"standard","title":"TFM-4AS-1","displaytitle":"TFM-4AS-1","namespace":{"id":0,"text":""},"wikibase_item":"Q28131997","titles":{"canonical":"TFM-4AS-1","normalized":"TFM-4AS-1","display":"TFM-4AS-1"},"pageid":52426484,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/64/TFM-4AS-1.svg/330px-TFM-4AS-1.svg.png","width":320,"height":201},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/64/TFM-4AS-1.svg/1565px-TFM-4AS-1.svg.png","width":1565,"height":985},"lang":"en","dir":"ltr","revision":"1274127118","tid":"4c57bf55-e3d9-11ef-bbf3-3228476a3b4b","timestamp":"2025-02-05T15:53:10Z","description":"Abandoned drug","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/TFM-4AS-1","revisions":"https://en.wikipedia.org/wiki/TFM-4AS-1?action=history","edit":"https://en.wikipedia.org/wiki/TFM-4AS-1?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:TFM-4AS-1"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/TFM-4AS-1","revisions":"https://en.m.wikipedia.org/wiki/Special:History/TFM-4AS-1","edit":"https://en.m.wikipedia.org/wiki/TFM-4AS-1?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:TFM-4AS-1"}},"extract":"TFM-4AS-1 is a dual selective androgen receptor modulator (SARM) and 5α-reductase inhibitor. It is a potent and selective partial agonist (Emax = 55%) of the androgen receptor (IC50 = 30 nM) and inhibitor of 5α-reductase types I and II (IC50 = 2 and 3 nM, respectively). TFM-4AS-1 shows tissue-selective androgenic effects; it promotes the accumulation of bone and muscle mass and has reduced effects in reproductive tissues and sebaceous glands. In an animal study, TFM-4AS-1 stimulated sebaceous gland formation only 31% as much as dihydrotestosterone (DHT) at doses that were as anabolic or more so than DHT. In addition, TFM-4AS-1 only weakly promoted growth of the prostate gland and it partially antagonized the actions of DHT in the seminal vesicles and endogenous androgens in the prostate gland. Structurally, TFM-4AS-1 is a 4-azasteroid. A structurally related and more advanced version of TFM-4AS-1, MK-0773, was developed and pursued for potential pharmaceutical use.","extract_html":"
TFM-4AS-1 is a dual selective androgen receptor modulator (SARM) and 5α-reductase inhibitor. It is a potent and selective partial agonist (Emax = 55%) of the androgen receptor (IC50 = 30 nM) and inhibitor of 5α-reductase types I and II (IC50 = 2 and 3 nM, respectively). TFM-4AS-1 shows tissue-selective androgenic effects; it promotes the accumulation of bone and muscle mass and has reduced effects in reproductive tissues and sebaceous glands. In an animal study, TFM-4AS-1 stimulated sebaceous gland formation only 31% as much as dihydrotestosterone (DHT) at doses that were as anabolic or more so than DHT. In addition, TFM-4AS-1 only weakly promoted growth of the prostate gland and it partially antagonized the actions of DHT in the seminal vesicles and endogenous androgens in the prostate gland. Structurally, TFM-4AS-1 is a 4-azasteroid. A structurally related and more advanced version of TFM-4AS-1, MK-0773, was developed and pursued for potential pharmaceutical use.
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